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The former generally refers to the biphasic dose-response effects of single, often isolated, bioactive compounds (hormetins), such as resveratrol or curcumin

In these transgenic mice, optogenetic stimulation of the circuit connecting the posterior basolateral amygdala (BLA) to calbindin-positive neurons in the ventral hippocampal CA1 alleviates anxiety-like behavior, suggesting hypoactivity of the calbindin-positive neurons (Pi et al., 2020)

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