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Semaglutide may be unsuitable or require additional caution in patients who: are pregnant, breastfeeding or trying to conceive have a history of pancreatitis have severe gastrointestinal disease have delayed stomach emptying have significant kidney or liver impairment use insulin or medicines that can cause hypoglycaemia have diabetic retinopathy have an active or previous eating disorder have experienced a serious allergic reaction to semaglutide already use another GLP-1 or GIP/GLP-1 medicine are due to undergo surgery, sedation or general anaesthesia These factors are not all automatic exclusions

6 GLP agonists have the ability to decrease blood pressure and decrease plaque formation

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This also means the counteracted oxidative stress was as a result of the lysis of endothelial cells (Vukojevic et al., 2018)