There are few negative side effects from this supplement at reasonable doses
Sarris J, Oliver G, Camfield DA, Dean OM, Dowling N, Smith DJ, et al
Preclinical, randomized phase 1, and compassionate use evaluation of REGN4461, a leptin receptor agonist antibody for leptin deficiency
[12] These effects are similar to those seen with other low-calorie sweeteners and typically resolve with reduced intake
Because no trial has directly tested any of these ingredients alongside semaglutide or tirzepatide, claims must stay within substantiated structure-function language and avoid implying the product treats obesity or replaces the medication [2]