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Using multivariate regression models, improvements in insulin sensitivity were mostly associated with body weight reduction and only partly attributed to tirzepatide treatment, whereas enhancements in beta-cell function, and in particular with -GS and ISR5.4 mmol/L, showed an inverse relationship with percentage change in body weight and were mostly associated with tirzepatide treatment [17]

Many patients may require both medications simultaneouslyfor instance, someone with rheumatoid arthritis requiring corticosteroid therapy who also has obesity and associated metabolic complications

*Correspondence: Juan Huang, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

He currently holds a brown belt in the martial art under Josh Vogel

Agardh, E., Allebeck, P., Hallqvist, J., Moradi, T