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In vitro experiments demonstrated that agrin treatment significantly downregulated PDGFR and claudin-5 expression in a blood-brain barrier co-culture model comprising human brain microvascular endothelial cells and pericytes, suggesting that agrin may induce pericyte death and impair the integrity of the blood-brain barrier
A small drop of blood or mild transient stinging is normal
JPEN J Parenter Enter Nutr
Conversely, differentiation defects in skin cancer cells were linked to the abnormal cellular localization of defective nicotinic acid receptors (62)
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