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The amino acid sequence is amended to switch a lysine for an arginine, leaving only one lysine in the sequence, which is used to introduce the fatty acid side chain
A falling number on the scale is not always a sign of better metabolic health, especially if what is falling includes the muscle that patients need for long-term metabolic function, glucose disposal, and quality of life
While most GI side effects (nausea, vomiting and diarrhoea) caused by GLP-1RAs are mild to moderate and short-lived [5, 6, 50], they can be minimised by recommending simple measures such as eating smaller meals, stopping eating as soon as the patient feels full, and injecting at mealtimes
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