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Due to the lack of actionable industry standards and regulation, the misuse of anti-disease drugs and abnormal liver lipid metabolism in bullfrogs have become a major obstacle to the development of bullfrog aquaculture industry

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Seemingly disparate conditions such as adolescents who are normal-weight but physically inactive [Reference Ischander, Zaldivar, Eliakim, Nussbaum, Dunton and Leu6], those who exercise at excessive levels [Reference Nemet, Connolly and Pontello-Pescatello7,Reference Javed, Tebben, Fischer and Lteif8], and obese children and adolescents [Reference Petek, Petek, Monik and Varda9], all manifest harmful growth patterns and, often, elevated inflammation associated with increased cardiovascular disease risk

Four significant pathways were identified: CRMPs in Sema3A signaling, KEAP1-NFE2L2 pathway, Purinergic signaling in leishmaniasis infection, and Collagen degradation (Fig