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CLA (Conjugated Linoleic Acid) : Known to reduce body fat, CLA is a fatty acid that supports lean muscle gain while promoting fat loss

If getting enough protein is a challenge, whey isolate protein is fast-digesting, easy on the stomach, and generally well-tolerated, making it ideal for individuals on GLP-1s

Apart from this, metformin can cause changes in the microbial composition of the intestinal tract (Vallianou et al., 2019), increased lactic acid production (Misbin et al., 1998), and increased concentrations of glucagon-like peptide-1 (GLP-1) and bile acids (Mannucci et al., 2004

But if they become severe or persistent, working closely with a clinician to pause treatment or lower the dose can help

There's no standard of care for how to de-escalate therapy, and so different physicians have different experiences and practices, adds Biermann