Standard protocols include competitive binding assays using radiolabelled ligands, receptor activation measurements through cAMP accumulation, and downstream signalling analysis through various intracellular pathways
Novo Nordisk has also invested in a new generation of small-molecule CB1R inverse agonists, which are currently in phase I clinical trials
These early changes reflect the peptides activation of lipolytic pathways and increased fat oxidation, though visible physical changes are not yet apparent
Apart from that, it may also show neuroprotective properties and act as an agent against collagen production
A 12-week facial cream study enrolling 71 women with mild to advanced photoaging documented increased skin density and thickness, reduced laxity, improved clarity, and reduced fine lines with depth of wrinkles decreased