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And they connect the receptor to the cell internalization machinery, specifically clathrin-coated pits that pull the receptor off the cell surface and into intracellular compartments called endosomes

The rats were maintained in an animal room with an air-conditioned barrier system at an ambient temperature of 25C 2C, relative humidity of 50% 10%, and a 12 h light/dark cycle

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Available from: Sikiric P, Ruman R, Turkovi B, Sever M, Klicek R, Radi B, et al