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Total societal value is roughly $4.1 trillion
The patient characteristics include age, sex, weight, and body mass index (BMI)
Hypoxia-preconditioned BMSCs secrete functional paracrine molecules such as VEGF and miR-126, which not only inhibit right ventricular cardiomyocyte apoptosis, alleviate inflammation and fibrosis, but also improve pulmonary vascular remodeling and reduce mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR) ( 4 Factors affecting the efficacy of MSCs therapy for PH The properties and functions of MSCs are influenced by various factors, including donor age, culture techniques, and preservation methods
Simonsen E, Lund LC, Ernst MT, et al
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