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Additionally, older adults have a harder time absorbing vitamin B12

Anyone taking methyl-donor-sensitive medications (some psychiatric drugs, methotrexate, methylated B-vitamin protocols at high doses): NNMT shares the methyl donor SAM, so theoretical interactions exist

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As we age, our bodies can become deficient in key vitamins and minerals because we don't absorb them as efficiently as when we were young

NNMT also lowers NAD+, affecting how our bodies use energy and handle fat