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The antibody Fab7F38 appears to function by providing enhanced soluble surface area for crystal lattice packing, and indeed Fab7F38-bound GLP-1R can also assume an active conformation as shown by EM studies (see below), suggesting that Fab7F38 does not interfere with the conformational flexibility of the ECD during crystallization
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Jorgen Scheel-Kruger, Peter Moldt, Frank Watjen
Sustainable Results, Not Short-Term Fixes Successful weight loss requires time, consistency, and metabolic recalibration
- What real-world data will be needed to demonstrate long-term outcome benefits
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