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A systematic review and meta-analysis found that creatine supplementation was associated with a small but statistically significant increase in serum creatinine of approximately 0.07 micromol/L

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Exendin-4 has been shown to reduce advanced glycation end product (AGE)-induced interleukin (IL)-6 and TNF- production, the expression of receptor for AGE (RAGE), and cell death in mesangial cells (Wang et al., 2014)

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