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Key Insights & Takeaways: 1 A Paradigm Shift Meets Prescriber Inertia: Despite being a first-in-class mechanismapproved in 2024 as the only novel schizophrenia therapy in decadesCOBENFY (xanomeline and trospium chloride) US HCP faces deeply ingrained D2 prescribing habits, as noted by BMS leadership

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An inspector wrote that Strive produced large amounts of odd strengths/doses in anticipation of prescriptions, and that different providers whose prescriptions were fulfilled by Strive used identical language to justify compounding what regulators described as essential copies of commercially available FDA-approved GLP-1 drugs

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