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Endocrinology, Diabetes & Metabolism

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Considering that OPG and RANKL are mainly secreted by osteoblasts to regulate bone metabolism, the inhibition of MOTS-c-induced osteoclastogenesis may be caused by an increase in the OPG/RANKL ratio

However, cost and side effects were cited more often as reasons for discontinuation

*Correspondence: Li Chen, [email protected] This article was submitted to Gut Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers