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When melanin production increases or becomes irregular, the skin can appear darker or develop hyperpigmentation

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IGFBP-2, an important member of the insulin-like growth factor binding protein family, is able to regulate a variety of cell signaling pathways to influence tumor progression

the studies looking more specifically at mechanistic pathways of action will typically be focused on micro-analysis, whereas those looking at the level of tissue healing on a macro-scale will be focused on biomechanical and functional measures