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Those are not the same risk profiles, and its worth being honest with yourself about which category you fall into
By employing a conditional gene expression strategy on an ApoE knockout background to eliminate interference from endogenous central ApoE, the study demonstrated that peripheral expression of ApoE4 alone is sufficient to induce memory impairment, BBB leakage, and perivascular gliosis, with a severity comparable to that observed in systemic ApoE4 expression models [88]
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Studied for synergistic effects on lean mass and metabolic biology
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