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Understanding the limitations of current evidence A responsible discussion of PTD-DBM requires clear-eyed assessment of what remains unknown

AMPK activation is the same pathway triggered by exercise, caloric restriction, and drugs like metformin

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Recent advances in neuroimaging technology allowing for in vivo quantification of GSH levels in the brain have shown decreased GSH in patients with MS compared to healthy controls, with the degree of depletion correlating with disease severity and showing parallel longitudinal decline over time (Mandal et al., 2015)

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