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That follow-up trial, involving 536 obese adults over 24 weeks, failed to meet its primary efficacy endpoint, meaning the fat-loss effect seen at the smaller scale did not hold up in the pivotal study

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Participants who received the highest dose of orforglipron, 36 milligrams, lost 11.2% of their body weight - about 25 pounds on average - over more than 16 months

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Candidates who typically benefit most from semaglutide therapy include individuals with obesity (defined medically as a body mass index of 30 or higher) or those who are overweight (with a BMI of 27 or higher) and experiencing weight-related health conditions such as elevated cholesterol, diabetes, or high blood pressure