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The parameters were assessed by immunohistochemistry and fluorescence light microscopy in nine female participants aged 4468 years
Importantly, these findings demonstrate that while the depletion of glutamate by GCLC is a metabolic vulnerability under nutrient replete conditions, we find that it confers an advantage under cysteine starved conditions
doi:10.1200/JCO.2009.23.4823 28Sternberg CN, Davis ID, Mardiak J,
E.et al (2013)
Consequently, this intervention reduces the accumulation of histone lactylation and suppresses the expression of Fas, ultimately alleviating necroptotic cell death and renal impairment in DKD models (28)
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