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Prx1 Cys83 binds to cullin-3, a ubiquitin ligase modulating Nrf2 ubiquitination [150] , and thereby inhibits degradation of Nrf2 allowing transcription of anti-ferroptotic enzymes [149]

It will be interesting to identify the regulatory mechanisms underlying molecular and biochemical responses of different classes of GSTs

The copper component also serves as a cofactor for superoxide dismutase (SOD-1 and SOD-3), providing direct antioxidant protection at the tissue level

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Approximately 25 years ago, it was shown that these compounds produce their effects by blocking neurotransmission at NMDA-type glutamate receptors ( Figure 1 ), giving rise to current glutamatergic theories