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developed BX-001 N nanoparticles by conjugating bilirubin 3 with polyethylene glycol (PEG) through self-assembly, enhancing bilirubins water solubility and in vivo stability

doi: 10.1038/s41416-023-02204-2 55 MorettiIFLerarioAMSolaPRMacedo-da-SilvaJBaptista M daSPalmisanoGet al

It works by binding to the ghrelin receptor (GHS-R1a) in the hypothalamus and pituitary, triggering a calcium/PKC signaling cascade that releases stored growth hormone, while separately blunting somatostatin's inhibitory signal

The concentration for 50% of maximal effect (EC 50 ) of GaM was about 14 molL 1 , and cytotoxicity was not observed at a concentration of at least 200 molL 1

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