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& Sakaguchi, S

Preclinical studies reveal sex-specific regulatory mechanisms: in female HF mice, the vitamin B complex (B3/B9/B12) optimizes energy supply through lipid metabolism remodeling while inhibiting Col1a1/Col3 gene expression and NLRP3 inflammasome activation, significantly reducing cardiopulmonary fibrosis and inflammatory cytokine levels

healthier lifestyles often include sufficient B12 intake through balanced diets

Taking supplements without medical advice Combining different supplements or taking excessive doses may lead to liver or kidney toxicity, so always seek medical advice

Acknowledgements The authors would like to thank Victoria Jeter, Ph.D., of Precision AQ (Bethesda, Maryland, USA), for writing and editing assistance