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The South African Health Products Regulatory Authority (SAHPRA) has approved only three injectable medicines containing GLP1s: Novo Nordisks liraglutide and its predecessor semaglutide, and Eli Lillys tirzepatide
On December 22, 2025, the FDA approved Novo Nordisk's once-daily oral semaglutide (Wegovy pill, 25 mg) for chronic weight management and cardiovascular risk reduction (FDA / Novo Nordisk, 2025)
If you lose 20 pounds on semaglutide but do not adopt lasting dietary habits or increase physical activity, your body recognizes the weight loss as temporary and works to restore the previous set point
For context on what is possible when you combine these tools effectively, the guide on building muscle while on GLP-1 covers the mechanisms and strategies in depth
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