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Cham: Springer Copyright 2016, The Author(s)

At this time, retatrutide, one of the best-known triple hormone receptor agonists, is still investigational and has not been approved by any regulatory agency for routine patient use

It has been extensively characterised in preclinical in-vitro and in-vivo models for its cytoprotective, angiogenic, and anti-inflammatory properties across a range of tissue types

At present, we have two highly effective drugs on the market with strong safety profilestirzepatide (Mounjaro) and semaglutide (Wegovy)which are considered essential therapies

This happens not because tirzepatide itself damages blood vessels, but because of the mechanical trauma of the injection