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Nature 628 , 154161 (2024)
Different guidelines [1, 2] have shown the importance of reaching and keeping haemoglobin A1c (A1c) in target
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Biochemistry 40 (9), 28602869
Reductions in body weight were significantly greater with the LY3298176 1.5 mg, 4.5 mg and 10 mg doses versus placebo in MAD HS (LSM difference [95% CI]: -1.75 kg [-3.38, -0.12], -5.09 kg [-6.72, -3.46] and -4.61 kg [-6.21, -3.01], respectively) and doses of 10 mg and 15 mg had a relevant effect in T2DM patients (LSM difference [95% CI]: -2.62 kg [-3.79, -1.45] and -2.07 kg [-3.25, -0.88], respectively
However, monitor liver enzymes at baseline and periodically during treatment to distinguish beneficial reductions from rare cases of drug induced liver injury
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