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While glutathione is generally safe, excessively high doses are unnecessary and may be cleared by the kidneys before they can be used

Reactive oxygen species: from harmful molecules to fine-tuning regulators of stem cell niche maintenance

Black B, Silva LBR, Hu G, Qu X, Smith DFQ, Magaa AA, Horianopoulos LC, Caza M, Attarian R, Foster LJ et al (2024) Glutathione-mediated redox regulation in Cryptococcus neoformans impacts virulence

Thiol-metal interactions, known as coordination bonds or metal-thiolate complexes, are characterized by the binding of the sulfur atom to the metal center, often resulting in stable coordination geometries

Furthermore, O2 is produced during a sequence of events known as the respiratory burst that activated neutrophils go through (132)