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TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: compounds pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development

Semaglutide 2.4mg (Wegovy) is contraindicated in pregnancy, while other GLP-1 receptor agonists are generally not recommended

Implications During Pregnancy: While the benefits of GLP-1 in weight management are promising, studies like those in the British Journal of Clinical Pharmacology emphasize the need for cautious consideration during pregnancy

It has also shown promise in reducing symptoms of depression and anxiety, contributing to overall mental health

For extended trips, research should be conducted on refrigeration availability at the destination, and consideration should be given to bringing extra supplies in case of travel delays