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Similarly, DSePA, another interesting organoselenium compound, has shown potent efficacy as a lung-specific radiomitigator through inducing the expressions rather than mimicking the activities of seleno-GPxs, thus warranting future clinical studies [61, 62]

Cleavage of an overexpressed GGT enzyme on the cell membrane and luminal surface of tumor cells having higher metabolic activity converts neutral nanoparticles into cationic ones, resulting in deep tumor penetration and enhanced anti-cancer properties due to caveolae-mediated endocytosis in the BxPC3 orthotropic pancreatic cancer murine model [352]

10.1002/fsn3.4263 229 QuinnV.GraberJ.SedlacekM

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