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2.4 mg once weekly is the highest cagrilintide dose used in clinical development, including the CagriSema program
Yet, plasma concentrations of vitamin C 50 mol/L are sufficient to saturate muscle tissue vitamin C
Future studies should explore more effective combinations of lifestyle interventions and pharmacotherapy, with emphasis on maintaining metabolic health and preserving lean mass, particularly through nutritional support and resistance training, among people at higher risk of sarcopenia
Preliminary data look favourable but published human RCTs are limited
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