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Direct quotation from the 2023 OMA guidelines: "Anti-obesity medication selection should be driven by efficacy data, individual patient response, side-effect profile, and access rather than by any single algorithm." OMA clinical practice guidelines are available at pubmed.ncbi.nlm.nih.gov

The people who navigate stalls most successfully, who do not panic, who make measured adjustments, who trust the process, are the people who maintain their results long-term

5fi and Extended Data Fig

As mentioned, the GLP-1 drugs work best alongside lifestyle and diet changes, as well as exercise, so start there

However, adding B12 without a documented deficiency offers no proven benefit and represents unnecessary cost and injection frequency