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Last reviewed: November 16, 2025 Last reviewed: November 16, 2025 Comirnaty (Pfizer-BioNTech) mRNA COVID-19 vaccine is FDA-licensed for use in ages 5 years through 64 years with at least one underlying condition that puts them at risk for severe COVID-19 infection and individuals 65 years and older mNexspike (Moderna) is FDA-licensed for use in ages 12 through 64 years with at least one underlying condition that puts them at risk for severe COVID-19 infection and individuals 65 years and older Nuvaxovid (Sanofi-Novavax) is FDA-licensed for use in ages 12 through 64 years with at least one underlying condition that puts them at risk for severe COVID-19 infection and individuals 65 years and older Spikevax (Moderna) mRNA COVID-19 vaccine is FDA-licensed for use in ages 6 months through 64 years with at least one underlying condition that puts them at risk for severe COVID-19 infection and individuals 65 years and older Although the FDA licenses are limited in the age group younger than 65 years to those with underlying conditions that put them at risk for severe COVID-19 infection, the ACIP has recommended use based on individual decision-making (i.e., shared clinical decision-making) for all people age 6 months and older

In KFFs 2024 annual budget survey, 13 states under Medicaid fee-for-service contracts cover GLP-1s for obesity treatment, and most require prior authorization for prescription approval

Referral to registered dietitians, behavioral health specialists, or comprehensive weight management programs can provide additional support for sustained behavior change and weight maintenance, whether patients continue medication or attempt discontinuation with close monitoring

These signals serve to recruit monocyte-derived macrophages, neutrophils, and T-helper cells (Th1 and Th17) to the inflammatory niche (167, 168)

This is particularly relevant for researchers studying mechanisms of insulin secretion improvement in type 2 diabetes models