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The cohort included 6696 patients who added an SGLT-2 inhibitor to their GLP-1 receptor agonist treatment, who were matched to an equal number of patients who continued their treatment with GLP-1 receptor agonists (fig 1)
When a complete allose molecule coats the lower intestinal wall, these receptors, upon sensing its intense sweetness, immediately signal L cells to rapidly and profusely release GLP-1 into the bloodstream
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One widely discussed series published in the Journal of Clinical Psychiatry described patients whose alcohol consumption dropped substantially after starting semaglutide, often without any conscious effort to reduce drinking
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