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The mechanism of action involves several pathways: Appetite regulation : Semaglutide acts on receptors in the brain (particularly in the hypothalamus) to reduce hunger and increase feelings of fullness, leading to decreased calorie intake

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That stems from a 1.5% absolute reduction, from 8.0% in placebo-treated patients to 6.5% in those taking the glucagon-like peptide-1 (GLP-1) receptor agonist, A

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