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doi: 10.1111/dom.12084 23 ArslanianSAHannonTZeitlerPChaoLCBoucher-BerryCBarrientos-PrezMet al

[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy

The risk is not only the sequence Even where a molecule is biologically plausible, the product introduces a second layer of risk such as sterility and endotoxin contamination, incorrect peptide identity or concentration, degradation during storage, aggregation and immunogenicity, synthesis-related impurities, injection-site infection or granuloma, unpredictable systemic exposure and an absence of long-term carcinogenicity and reproductive data

It also contains glutathione, which acts as an antioxidant and, at the skin level, treats pigmentation and lightens the complexion

The NICE guidelines recognise GLP-1 receptor agonists as valuable treatment options for type 2 diabetes when other therapies have proven insufficient