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Mechanisms of Ageing and Development (PubMed) (2004) 9

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However, GI side effects are common during titration, with nausea, vomiting, and diarrhea increasing at higher doses, and discontinuation rates as high as 25% at the 15 mg level

Hydration and blood volume status Monitor hydration status, especially in elderly patients or those with renal impairment, as SGLT2 inhibitors increase urinary excretion and may lead to dehydration or hypotension

Although all types contribute to energy metabolism, they differ in their absorption and their roles in the body