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At baseline and at weeks 8 and 12, a clinician should assess fasting insulin and HOMA-IR (the homeostasis model assessment of insulin resistance, a calculated index derived from fasting glucose and insulin), HbA1c, high-sensitivity C-reactive protein as an inflammatory marker, and body composition by DEXA scan or bioelectrical impedance
doi:10.1007/s10067-016-3168-2
This systemic approach differs fundamentally from pharmaceutical interventions that target single pathways
& Lers, G
Fine lines and early wrinkles often show up when the support structure under the skin becomes thinner
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