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Roopchand, D

Using this compound as a marker of cobalamin deficiency, we have been able to demonstrate that cats and dogs with very low serum cobalamin do indeed have a significant tissue-level cobalamin deficiency (Figure 2)

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Specifically, they had seen that B12 and folate pools, as assessed by plasma homocysteine and methylmalonic acid, correlated with severe toxicity, with high homocysteine levels indicating folate deficiency

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