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Patients who approach lipotropic injections with realistic expectations and a commitment to lifestyle changes tend to see the best outcomes
Patients can easily apply and remove the patch without the need for injection training
Interestingly, chronic oral administration of rotenone to rodents in vivo induces many key features of PD, including selectively and progressive nigrostriatal DA neurodegeneration, abnormal behaviours (not seen in the MPTP mouse model) and formation of Lewy bodies (not seen in either the MPTP or 6-OHDA mouse model) 30
Curr Clin Pharmacol
They ask whether the benefit was accompanied by acceptable tolerability, whether side effects clustered early during dose escalation, and whether there were any patterns that might affect wider use in people with co-existing conditions
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