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Clinical data shows GLP-1 medications produce average weight loss of 10-15% over 16 weeks when combined with lifestyle changes

Vermeulen RC, Scholte HR

The SELECT cardiovascular outcomes trial (N=17,604), published in NEJM 2023 (DOI: 10.1056/NEJMoa2307563), demonstrated a 20% reduction in major adverse cardiovascular events (MACE) -- the composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke -- in overweight or obese adults without diabetes

Eating too close to the shot If insulin spikes from a meal are still active, the GH pulse gets blunted

In PBMC, acetylcarnitine concentrations were below the detection limit