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Revisiting proven dual-acting small molecules in validated mouse and hamster models could make those studies more robustand open new options for differentiation
Inositol-related compounds are also involved in cellular signaling pathways
Yusta B, Baggio LL, Koehler J, et al
Overall, the mechanisms of semaglutide action can be described as a systemic, weight-focused intervention that targets caloric overload, insulin resistance, and pro-inflammatory adipokine profiles, all of which contribute to the liver pathology of MASH
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