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The HEIDI test manifested that the analyses of GLP1R with background DR ( P = 0.29), and severe nonproliferative DR ( P = 0.42) were not due to linkage

For comparison with published CNS GIPR KO models 18 and CNS GLP-1R KO models 19,20 , Gipr Syn/ mice were further characterized in two independent cohorts (Extended Data Fig