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The anti-inflammatory effects of GLP-1 receptor agonists appear to operate through pathways that are activated at lower receptor occupancy levels than those required for metabolic effects
15, Clinical Kidney Journal
A gradual titration schedule starting at a low dose significantly reduces their severity
The clustering between specific biological and clinical features has been postulated to identify a theoretical dimension labelled immuno-metabolic depression (IMD) [2] (aligning with the Research Domain Criteria (RDoC) framework [52]
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