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doi: 10.1210/endo.133.6.8243312 42 ThorensB

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

This ensures maximum absorption and utilization by the body, bypassing the digestive system, where oral supplements may be less effective

doi: 10.1007/s11154-020-09609-x 16 TreesukosolYSmithKRSpectorAC

Across multiple drug classes, common patterns emerge: Corticosteroids accelerate protein breakdown and deplete calcium, vitamin D, magnesium, zinc, and vitamin Cnutrients required for bone strength, collagen synthesis, and immune repair Acetaminophen consumes glutathione, increasing oxidative stress and impairing cellular recovery NSAIDs interfere with iron, folate, and vitamin C absorption while disrupting prostaglandin-driven tissue healing Opioids suppress endocrine and immune signaling necessary for regeneration Individually, these effects may appear modest