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tirzepatide and metabolism

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Comprised of TXN, thioredoxin reductase (TrxR), and nicotinamide adenine dinucleotide phosphate (NADPH), this system facilitates the reduction of oxidative GSH to its active form in response to NADPH [78], thereby supporting the removal of cytotoxic GSH by GPX4 [79, 80]

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Episodes may last for hours or several days and can become severe enough to cause dehydration, electrolyte imbalance, esophageal irritation, malnutrition, and repeated hospitalization

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While the risk of kidney injury risk is rare, it is often linked to dehydration from digestive side effects of the drug such as nausea and vomiting

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