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Patients should seek medical advice if headaches are accompanied by: Neurological symptoms : Vision changes, weakness, numbness, difficulty speaking, confusion, or loss of consciousness Severe nausea and vomiting : Particularly if unable to maintain adequate hydration or take medications for more than 24 hours Signs of dehydration : Markedly decreased urination, dark urine, dizziness, rapid heartbeat, or dry mucous membranes Fever or neck stiffness : Which may suggest infection requiring evaluation Changes in headache pattern : New characteristics in patients with pre-existing headache disorders New onset after age 50 : Headaches beginning later in life require evaluation Severe, persistent abdominal pain with or without vomiting : May indicate pancreatitis, a rare but serious side effect of GLP-1 medications requiring immediate medical attention Healthcare providers may recommend several approaches when evaluating persistent headaches

Published clinical literature should not be interpreted as use guidance for RUO materials

Biochem Biophys Res Commun 247:4816, PMID: 9642155 Reddy S, Jones AD, Cross CE, Wong PS, Van Der Vliet A (2000) Inactivation of creatine kinase by S -glutathionylation of the active-site cysteine residue