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Originally approved to help people with Type 2 diabetes, the class of medications known as GLP-1 agonists and dual GIP/GLP-1s quickly acquired a reputation for helping people shed stubborn pounds

B12 and the Brain A vitamin B12 deficiency is typically one of the first things checked in someone who is experiencing unexplained cognitive impairment, Yourman says, since not getting enough of the essential vitamin can cause memory problems and confusion

People who are already relatively lean (under 25% body fat for men or under 32% for women) may find that GLP-1 medications produce less dramatic weight loss but still improve body composition through targeted fat reduction

Those with a prior history of kidney stones have a higher baseline risk, and Wood says several other factors may increase vulnerability

PMID: 34687744 Biochem Pharmacol Single-cell RNA sequencing reveals beneficial mechanisms of Exendin-4 in autoimmune uveitis