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Earlier this month, the FDA put out a statement saying that it, too, was concerned about patients and healthcare professionals turning to unapproved versions of GLP-1 drugs as an option for weight loss, saying: "This can be risky for patients, as unapproved versions do not undergo FDA's review for safety, effectiveness, and quality before they are marketed." Tirzepatide was removed from the shortages list a few weeks ago, leading to restrictions on the sale of compounded versions

If the FDA removes tirzepatide from the drug shortage list, compounding pharmacies lose legal authority to prepare it under the shortage exemption

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In an animal study using 5-dihydrotestosterone + insulin treatment to simulate a miscarriage model in PCOS patients, NAC supplementation improved fetal survival rates in model mice by protecting mitochondrial function, restoring the balance of SOD1 and the Keap1/Nrf2 antioxidant response, reducing excessive ROS production, and mitigating placental formation defects [57]