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Moreover, NAD has a crucial role in glycolysis, the citric acid cycle, and oxidative phosphorylation, since it acts as a proton acceptor, generating NADH, its reduced form, which collaborates with mitochondrial proton gradient (14)

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These changes in the ultrastructure of rat testicular tissues indicated that the simulated high-altitude, low-pressure and hypoxic environment affects the tight junctions between rat Sertoli cells, mesenchymal cells and spermatogonia